microcrystalline cellulose msds fmc

Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. %PDF-1.3 common form is used in vitamin supplements or tablets. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . EMCOCEL XLM 90. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge CAS No. gac74 [#B6`Wnw7 If you are already a ChemPoint customer then sign up for access to our online ordering website. Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? Hi, let us know if you have any questions as you visit our website. cas:9032-51-3 msds CELLULOSE PAB. They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. Home. vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against (1962). Created Date: 2/10/2020 8:51:41 PM . Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. Looking for FMC'searnings news? stream A., and Smith, P. A. 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W MCC helps in the formation of spheres because of its . YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. MSDS Ref. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. stream if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. High performance lubricant that brings more to the tablet. 1 0 obj % In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. Cellulose microcrystalline for column chromatography. Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. Regulatory Information Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. Molecular weight: Not Applicable 1.5. MATERIAL SAFETY DATA SHEET. Page 1 of 8. Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. It . Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. Medium size standard MCC grade, suited for the majority of directly compressible actives. Microcrystalline Cellulose / Avicel PH-102. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. SUBSTANCE IDENTIFICATION 1.1. Microcrystalline cellulose (C6H10O5)n is refined wood pulp. Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. Report Category. FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. : 1. Revision No. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. Chemical Formula: (C6H10O5)n 1.4. cas:9000-11-7 msds Carboxymethyl cellulose. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. AVICEL RC 581. POLYOX resins are nonionic polyethylene oxide solubility polymers. 8 0 obj PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. There may be more fiber in your food than you realized. Synergies to simplify formulation challenges and reduce operational costs. Learn about FMC's differentiated biologically-based crop solutions. Manufactured by: China . 130. Manufacturer: FMC BioPolymer. ( Heavy metals, % NMT 0.001 J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. Microcrystalline Cellulose. We are artists at heart and creators by nature. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL HMo@9, U Q!R/1*;` AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. CAS #: 9004-34-6 1.6. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; Material safety data sheet - FMC Corporation. Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . 1.3. 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. No. PDF (2.77 mb) 2021 FMC Sustainability Report. Microcrystalline Cellulose NF. 5 0 obj Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. endobj ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" : CL-611NF Date Approved: 01/13/2010. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. It is also used in plaque assays for counting. Molecular Weight null. PharmaCentral 2021 . The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. No. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. Date Approved: 05/25/2010. [FMC Study Number I92-1464]. 1 0 obj All rights reserved. endobj II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. 4. Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> Microcrystalline Cellulose E460 MSDS 1. ChemicalBook. endobj <> In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). undefined. FMC, JRS and Mingtai were estimated to hold for . Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. The most. . Molecular weight: Not Applicable 1.5. /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. << /Type/Page By producing Avicel . We respect your privacy FMC Privacy Policy. Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. Microcrystalline Cellulose / Avicel PH-102. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Browse Avicel PH-101 and related products at MilliporeSigma. ( The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. Avicel Microcrystalline Cellulose: Chemical Identifiers. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. No. Watch Now. Avicel PC 611 (FMC Biopolymer) Supplied by. Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. % This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication. 1.3. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. 6 No. In extrusion-spheronisation, it is the excipient of choice. The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. : 160182 Date Approved: 05/25/2010 Revision No. Remove From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. ). For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. Are you looking for information about products and services by region? Request media, explore upcoming events and read our latest updates. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . q86@on$^X_HuH;3` xv}O2' H~KEe9>G/,:9\i 1 0 obj A family of polysaccharide products that allow distinctive drug delivery solutions. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. : 5. We can send by Fedex, by ship or by plane according to international rules. METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. All Rights Reserved. ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . The aqueous solution to barrier membrane coating. <> SDS. *r_ *?~4$ &0Y# Product Name Cellulose microcrystalline. Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. These, in turn, are assembled into fibrils in the cell wall. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. No. PDF (28.38 mb) 2022 Corporate Fact Sheet. Trademarks: Avicel PH-102. GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. ( The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . Earth Supplied Products LLC. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? q9;v80q>jZ EMCOCEL 90 M. 130. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. It is . w !1AQaq"2B #3Rbr MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. %PDF-1.4 It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. ( IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 6 0 R/Group<>/Tabs/S>> . The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. << The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. Protect them from sunshine or rain. Microcrystalline cellulose -The oldest polymer finds new industrial uses,. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream Are you sure you want to delete your template? Battista, O. {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream The data shown below apply only to Avicel PH 101. Avicel PH-200 microcrystalline cellulose NF, Ph. Have an order or account question? IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm 4 0 obj Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. Avicel PC 611 (FMC Biopolymer) . However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. These grades have particle sizes ranging from <30 to approximately 200. CAS #: 9004-34-6 Have an order or account question, find answers in our Online Support articles. Apply today! Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends.

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